liquid paraffin and milk of magnesia oral emulsion
The patients and parents were asked regarding the compliance with treatment, side-effects, number of bowel movements after treatment and willingness to try similar treatment if faecal impaction recurred. Childhood constipation is a common pediatric healthcare problem. We found 14 systematic reviews and RCTs that met our inclusion criteria. Functional constipation is a common and often enduring problem in childhood. Carrying out well-defined placebo-controlled trials in children should be the next step before using these drugs. The clinical efficacy and side effects were monitored. Safety of drugs was assessed with the evaluation of clinical adverse effects.
Nausea and abdominal pain were more common side effects in group 1 and 2 respectively. Despite the widespread use of osmotic and stimulant laxatives by health professionals to manage constipation in children, there has been a long standing paucity of high quality evidence to support this practice. da dieta que têm lugar durante o primeiro ano de vida. Introduction: We set out to evaluate the efficacy and safety of osmotic and stimulant laxatives used to treat functional childhood constipation. In total 10 studies were of high quality. Common adverse events in these studies included diarrhoea, abdominal pain, nausea, vomiting and pruritis ani. No, taking a higher than the recommended dose may not be more effective, rather it may increase the chances of having serious side effects and toxicity. In up to 95 % of the cases, the problem is functional constipation. Treatment of functional constipation requires a combination of parent and patient education, nutritional intervention, behavioral intervention, pharmacotherapy, close follow-up, and long-term compliance with the treatment regimen. The treatment of first choice is oral laxatives, preferably polyethylene glycol. This study shows a clear advantage overall for the use of laxative medication, although the benefit may not be as great for children who are able to maintain regular toileting. responsável por 3% das consultas ao pediatra geral e por cerca de 30% All RCTs and the CCT were hospital based, of which 9 were conducted at a general paediatric department 16,19,27,29,31,33,35,47,48 and 11 were conducted in a paediatric gastroenterology department 14,26,36,40,43. Milk of Magnesia+Liquid Paraffin is used in the treatment of. This retrospective study analyzed medication use and stool outcomes of 36 children who received polyethylene glycol 3350 (PEG) or mineral oil (MO) after a spinal fusion. Results: both treatments led to a sustained improvement of symptoms, with more than 90% of patients responding to lactulose/liquid paraffin (>3 bowel movements in each treatment week), compared with the 83% observed in patients taking the psyllium/senna combination.
magnesia milk metaphosphate sodium small Prior art date 1936-06-18 Legal status (The legal status is an assumption and is not a legal conclusion.
37 compared lactulose to senna and found no significant difference in defecation frequency between the two treatments (limited evidence). It is mainly based on general rules and treatment with dietary fibers. In the PEG group, 90% refused the medication one or more times compared with 75% in the MO group. To determine and compare efficacy, safety and optimal dose of two laxatives, liquid paraffin and lactulose, in 40 children with chronic functional constipation. Meta-analysis of two studies (101 patients) comparing polyethylene glycol (PEG) with placebo showed a significantly increased number of stools per week with PEG (MD 2.61 stools per week, 95% CI 1.15 to 4.08). The symptom must be present for 1 month in infants and toddlers and 2 months in children and adolescents. Selection criteria: One child was noted to be allergic to PEG, but there were no other serious adverse events reported. Family satisfying and compliance were obviously more achieved in group 1 (87.5% vs 57.5%) than in Group 2 (P<0.001). Liquid paraffin patients reported less abdominal pain, straining and pain at defecation than children using lactulose. This review discusses the evaluation and management of functional constipation in the pediatric population and provides a summary of drug treatment options. In addition to education and behavioral changes, disimpaction and maintenance treatment with medications are the main pillars of successful outcome. Participants receiving high dose PEG (0.7 g/kg) had significantly more stools per week than low dose PEG (0.3 g/kg) participants (1 study, 90 participants, MD 1.30, 95% 0.76 to 1.84). Authors' conclusions: For continuous outcomes we calculated the mean difference (MD) and 95% confidence interval (CI) using a fixed-effect model. No serious adverse events were reported with either agent. A chart review found no statistical differences by group for number of bowel movements (BMs) before discharge (p = .37), time from procedure to BM, use of rescue cathartics (p = .55), or medication refusal (p = .37). esfi ncteriano, diagnóstico, prevalência, incidência, alergia alimentar, Usually, government's categorizes medicines that can be addictive as controlled substances. Constipation within childhood is an extremely common problem. A significant increase in defecation frequency, liquid paraffin group, 3 pre, versus, 12 post treatment per week and lactulose group: 3 pre, versus 8 post, per week was found. 169 children with encopresis and evidence of stool on plain abdominal radiograph were randomly allocated to receive multimodal (MM) therapy (laxatives plus behaviour modification; n = 83) or behaviour modification alone (BM; n = 86). If you are regularly missing doses, consider setting an alarm or asking a family member to remind you. We used the index of motor activity (IMA), expressed in cmH2O, for characterization of the motor function. Children with CTTs > 100 h were said to have pediatric slow-transit constipation (PSTC), while patients with CTTs < 100 h were said to have normal- or delayed-transit constipation (NDTC). ©2016 Society of Photo-Optical Instrumentation Engineers (SPIE). We investigated smooth muscle contraction by tenzometric method, studied the spontaneous and stimulated motility by ballonographic method. Patients were followed-up over 12 weeks. Milk of Magnesia+Liquid Paraffin should be used cautiously in patients with kidney problems. Besides, subjects were followed carefully for the side effects. Functional constipation is a clinical diagnosis; the evaluation primarily consists of a thorough medical history and a complete physical examination. However, the magnitude of this difference is quite small and may not be clinically significant. Good toileting behaviour was encouraged. The key to successful management is early diagnosis and prompt treatment with an emphasis on holistic care with multidisciplinary support where needed.
Thus, the results of the pooled analyses should be interpreted with caution because of quality and methodological concerns, as well as clinical heterogeneity, and short follow up. Some investigators in the United States have estimated the prevalence of constipation to be 1.2% to 8.0% in the general population. Administration of PEG 3350 were associated with less adverse events than liquid paraffin. Early diagnosis and treatment are key factors with respect to successful long-term outcome, as chronic constipation has a negative effect on the quality of life and is a burden for the public healthcare system. Lactulose and lactic acid bacteria offer a promising ingredient combination for future functional and special dietary foods in treating intestinal disturbances. Pharmacological treatment with laxatives consists of disimpaction, maintenance treatment, and weaning of medication. Nine clinical questions addressing diagnostic, therapeutic, and prognostic topics were formulated. The Subcommittee developed two algorithms to assist with medical management, one for older infants and children and the second for infants less than 1 year of age. PubMed, Medline, Embase and Evidence-Based Medicine Reviews databases were searched for blinded or randomized clinical trials and meta-analyses assessing the efficacy of nonstimulant and stimulant laxatives for the treatment of functional constipation. mucosa ou do plexo mioentérico. There is an urgent need for prospective comparative studies to investigate different treatment regimens and for longitudinal studies to examine the long-term outcome of chronic constipation and the factors that determine it. For continuous outcomes we calculated a mean difference (MD) and 95% confidence interval (CI) using a fixed-effect model. Results It has been proved that lipophilic agents, such as liquid paraffin, are capable of penetrating epithelium tissue and can serve as a carrier for drug delivery. Secondary outcome measures were side effects during 8 weeks of treatment. During first 4 weeks, improvement in stool consistency and frequency was significantly higher in liquid the paraffin group (P < 0.01 and P < 0.05, respectively).
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